| Registro completo |
| Provedor de dados: |
ArchiMer
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| País: |
France
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| Título: |
Autophagy plays an important role in protecting Pacific oysters from OsHV-1 and Vibrio aestuarianus infections
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| Autores: |
Moreau, Pierrick
Moreau, Kevin
Segarra, Amelie
Tourbiez, Delphine
Travers, Marie-agnes
Rubinsztein, David C.
Renault, Tristan
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| Data: |
2015-03
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| Ano: |
2015
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| Palavras-chave: |
Autophagy
Crassostrea gigas
OsHV-1
Pacific oyster
Vibrio aestuarianus
ATG
Autophagy-related
Atg8-PE
Atg8-phosphatidylethenolamine
DNA
Deoxyribonucleic acid
Hpi
Hours postinfection
LC3-II
Cleaved
Lipidated and autophagosome-associated form of LC3
MAP1LC3A
B (LC3A
B)
Microtubule-associated proteins 1 light chain 3 alpha
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| Resumo: |
Recent mass mortality outbreaks around the world in Pacific oysters, Crassostrea gigas, have seriously affected the aquaculture economy. Although the causes for these mortality outbreaks appear complex, infectious agents are involved. Two pathogens are associated with mass mortality outbreaks, the virus ostreid herpesvirus 1 (OsHV-1) and the bacterium Vibrio aestuarianus. Here we describe the interactions between these 2 pathogens and autophagy, a conserved intracellular pathway playing a key role in innate immunity. We show for the first time that autophagy pathway is present and functional in Pacific oysters and plays an important role to protect animals from infections. This study contributes to better understand the innate immune system of Pacific oysters.
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| Tipo: |
Text
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| Idioma: |
Inglês
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| Identificador: |
http://archimer.ifremer.fr/doc/00269/37989/36072.pdf
DOI:10.1080/15548627.2015.1017188
http://archimer.ifremer.fr/doc/00269/37989/
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| Editor: |
Taylor & Francis Inc
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| Relação: |
info:eu-repo/grantAgreement/EC/FP7/266157/EU//BIVALIFE
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| Formato: |
application/pdf
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| Fonte: |
Autophagy (1554-8627) (Taylor & Francis Inc), 2015-03 , Vol. 11 , N. 3 , P. 516-526
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| Direitos: |
2015 The Author(s). Published with license by Taylor & Francis Group, LLC
info:eu-repo/semantics/openAccess
restricted use
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